Ben Roethlisberger passed for 365 yards and two touchdowns as the host Pittsburgh Steelers finally found a way to beat Tom Brady and the New England Patriots 25-17 on Sunday.

Roethlisberger completed 36 of 50 passes and led the Steelers (6-2) on a series of clock-chewing drives, effectively keeping Brady and the top-ranked offense of New England (5-2) off the field. Pittsburgh held the ball for more than 39 minutes and survived a late rally to win its fourth straight following a 2-2 start.

Brady passed for two touchdowns but threw for a season-low 198 yards and couldn't get into any sort of rhythm while losing to the Steelers for just the second time in his career.

Rams 31, Saints 21: Steven Jackson scored two touchdowns and had his first 100-yard rushing game in three seasons to help host St. Louis (1-6) hold off New Orleans (5-3).

Drew Brees barely kept alive his touchdown pass streak in the final seconds a week after throwing five TDs in a 62-7 rout of the Colts.

Ravens 30, Cardinals 27: Billy Cundiff kicked a 25-yard field goal as time expired, Ray Rice scored a career-high three touchdowns, and host Baltimore (5-2) pulled off the biggest comeback in Ravens history, overcoming a 24-3 deficit to beat Arizona (1-6).

Arizona pulled even with a 45-yard field goal by Jay Feely with 8:55 left, but the Ravens won it with a 37-yard, beat-the-clock drive in the final minute.

Vikings 24, Panthers 21: At Charlotte, N.C., Ryan Longwell kicked a 31-yard field goal with 2:43 left, and Carolina's Olindo Mare missed from the same distance with 26 seconds left, handing the Panthers (2-6) a win over Minnesota (2-6).

Giants 20, Dolphins 17: At East Rutherford, N.J., Eli Manning threw a 25-yard touchdown pass to Victor Cruz with 5:58 left to lift New York (5-2) past Miami (0-7).

Manning hit 31 of 45 passes for 345 yards and two touchdowns in rallying the Giants from an 11-point first-half deficit.

Titans 27, Colts 10: At Nashville, Tenn., Former Seattle Seahawk Matt Hasselbeck threw for 224 yards and a touchdown, and Nate Washington scored twice as Tennessee (4-3) kept Indianapolis winless (0-8).

Texans 24, Jaguars 14: Arian Foster rushed for 112 yards and a touchdown, and host Houston (5-3) shut down rookie quarterback Blaine Gabbert and Jacksonville (2-6).

Matt Schaub threw a TD pass and ran for another score for Houston, off to its best eight-game start. The Texans also took one more step toward the franchise's first division title and playoff berth by improving to 3-0 in the AFC South.

Lions 45, Broncos 10: Detroit sacked Tim Tebow seven times and turned his two turnovers into touchdowns as visiting Detroit (6-2) beat Denver (2-5) to snap a two-game skid.

Cornerback Chris Houston had the fourth 100-yard interception return in team history and defensive end Cliff Avril got a sack, strip and scoop, rumbling 24 yards into the end zone with a fumble as part of Detroit's 45-point run after the Broncos had taken a 3-0 lead on their first drive.

Bills 23, Redskins 0: At Toronto, Ryan Fitzpatrick threw two touchdowns and the Bills defense had nine sacks over injury-riddled Washington (3-4) in Buffalo's (5-2) adopted home north of the border.

49ers 20, Browns 10: Frank Gore ran for both 125-plus yards and a touchdown in a fourth straight game and Michael Crabtree made his first TD reception of the season and host San Francisco (6-1) beat Cleveland (3-4).

Alex Smith completed 15 of 24 passes for 177 yards, leading the NFC West-leading 49ers to their fifth consecutive victory since an overtime loss to the Cowboys in Week 2.

Eagles 34, Cowboys 7: Michael Vick threw two touchdown passes, LeSean McCoy had a career-best 185 yards rushing and two scores and host Philadelphia (3-4) routed Dallas (3-4).

The Eagles dominated right from the start, improved to 13-0 after a bye under coach Andy Reid and snapped a five-game losing streak at Lincoln Financial Field that dated to last season.