Aaron Rodgers threw for 308 yards and two scores, while the Green Bay Packers withstood another 400-yard passing day from Carolina rookie Cam Newton to beat the Panthers 30-23 on Sunday in Charlotte, N.C.

A week after throwing for 422 yards, Newton topped himself by throwing for 432 yards and a touchdown. He also ran for a 4-yard touchdown with 37 seconds left to bring Carolina (0-2) within seven, but the Packers (2-0) recovered the onside kick to seal the victory.

Browns 27, Colts 19: At Indianapolis, Peyton Hillis ran for 94 yards and two touchdowns, Colt McCoy threw for 211 yards and a score and Cleveland (1-1) ended a five-game losing streak against Peyton Manning-less Indianapolis (0-2).

Manning likely will miss two months following his third neck surgery in 20 months. The Browns rebounded with their first win for new coach Pat Shurmur after a loss to the Bengals last week.

Saints 30, Bears 13: Drew Brees threw for three touchdowns and host New Orleans' (1-1) defense beat up on Jay Cutler and Chicago (1-1).

Brees' scoring strikes included a 79-yarder to Devery Henderson. Darren Sproles scored on a 12-yard swing pass and Robert Meachem had a 4-yard TD reception as the Saints bounced back from an opening week loss to Green Bay.

Bills 38, Raiders 35: At Orchard Park, N.Y., Ryan Fitzpatrick threw a 6-yard touchdown pass to David Nelson with 14 seconds left to cap a wild back-and-forth fourth quarter to lead Buffalo (2-0) over Oakland (1-1).

Patriots 35, Chargers 21: At Foxborough, Mass., Tom Brady threw for 423 yards six days after setting a single-game team record of 517 in leading New England (2-0) over San Diego (1-1).

Brady had three touchdown passes and tied for the third most yards passing in club history, going 31 of 40 with no interceptions as the Patriots scored on each of their four first-half possessions.

Cowboys 27, 49ers 24, OT: Playing with a fractured rib, Tony Romo hit Jesse Holley on a 77-yard completion in overtime to set up Dan Bailey's winning 19-yard field goal to lead Dallas (1-1) at San Francisco (1-1).

Bailey kicked a tying 48-yard field goal as time expired in regulation after missing an early 21-yard attempt. Romo completed five of six passes on the tying drive, connecting on consecutive throws to Holley before finding him again in OT.

Redskins 22, Cardinals 21: At Landover, Md., Graham Gano kicked a 34-yard field goal with 1:45 remaining as Washington (2-0) rallied from an eight-point, fourth-quarter deficit to beat Arizona (1-1).

The Redskins beat the Cardinals for the eighth time in a row. Santana Moss' 18-yard catch on fourth down with 5:17 remaining pulled Washington within two, but the 2-point conversion attempt failed.

Titans 26, Ravens 13: At Nashville, Tenn., Matt Hasselbeck threw for 358 yards and a touchdown, and Tennessee (1-1) gave new coach Mike Munchak a big win in the home opener, beating Baltimore (1-1).

With the Ravens focused on stopping Chris Johnson, Hasselbeck, the former Seattle Seahawk, attacked through the air. Kenny Britt caught nine passes for 135 yards and a TD, while Nate Washington caught seven passes for 99 yards. Rob Bironas also kicked four field goals as Tennessee held the ball for more than 35 minutes and outgained Baltimore 432-229 in total offense.

Lions 48, Chiefs 3: Matthew Stafford threw two of his four TD passes to Calvin Johnson and host Detroit (2-0) came away with its largest margin of victory in a regular season game to beat Kansas City (0-2).

The Lions broke the mark they set with a 44-0 win over expansion Jacksonville in 1995 and matched the record set in the 1957 NFL title game when they beat Cleveland 59-14.

Texans 23, Dolphins 13: Andre Johnson caught a 23-yard touchdown pass from Matt Schaub that helped visiting Houston get off to a 2-0 start, beating Miami (0-2).

Miami's sieve-like pass defense was no match for Johnson and Schaub, who threw for 230 yards and had a quarterback rating of 118.5. Johnson made seven catches for 93 yards.

Buccaneers 24, Vikings 20: At Minneapolis, LeGarrette Blount's 4-yard touchdown run with 31 seconds left lifted Tampa Bay (1-1) and completed another comeback by quarterback Josh Freeman - this time from a 17-0 halftime deficit, to edge Minnesota (0-2).

Eight of Freeman's 14 career victories have come when the Bucs went ahead in the fourth quarter or overtime. Given how overwhelmed they were before halftime, outgained 284 yards to 62 during the first two quarters, this might have been the most impressive.

Jets 32, Jaguars 3: At East Rutherford, N.J., Mark Sanchez threw two touchdown passes as the offense started quickly and Antonio Cromartie had two of New York's (2-0) four interceptions of Luke McCown to beat Jacksonville (1-1).

Broncos 24, Bengals 22: Kyle Orton threw two TD passes to Eric Decker, Willis McGahee ran for another score and host Denver (1-1) slipped past Cincinnati (1-1).

Andy Dalton, who bruised his right wrist and forearm in Cincinnati's win at Cleveland a week earlier, threw for 332 yards for the Bengals, hitting fellow rookie A.J. Green 10 times for 124 yards and Jerome Simpson four times for 136 yards.

Falcons 35, Eagles 31: Matt Ryan threw a career-high four touchdown passes and host Atlanta (1-1) rallied to beat the Philadelphia (1-1) after Michael Vick was knocked out with an injury late in the third quarter.