Democratic boundary breakers' night: Obama, Clinton, Harris

WILMINGTON, Del. (AP) — The Democrats' historic boundary breakers are joining forces at the party’s national convention in an unprecedented effort to mobilize the diverse coalition Joe Biden will need to defeat President Donald Trump this fall.

Barack Obama, the nation’s first Black president, and Hillary Clinton, the first woman nominated for president by a major party, are speaking on Biden’s behalf Tuesday night. And Kamala Harris, Biden’s running mate and the first Black woman on a major party ticket, will deliver highly anticipated remarks that will serve as her first introduction to millions of voters.

Just 76 days before the election, voters in both parties are as engaged in politics as they have ever been, even while battling a pandemic that has left more than 172,000 dead and millions more out of work. Having formally been nominated by their party, the Biden-Harris ticket is now the Democrats' best and only hope to deny Trump another four years in office.

The pandemic has forced Biden's team to abandon the traditional convention format in favor of an all-virtual affair that has eliminated much of the pomp and circumstance that typically defines political conventions. It's also produced opportunities to create new traditions.

On Tuesday night, Biden celebrated his formal nomination in a school library with his family. Instead of a Milwaukee convention hall as initially planned, the roll call of convention delegates played out in a combination of live and recorded video feeds from American landmarks packed with meaning: Alabama’s Edmund Pettus Bridge, the headwaters of the Mississippi River and Washington’s Black Lives Matter Plaza.

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Harris prepares to make history with VP acceptance speech

WILMINGTON, Del. (AP) — Kamala Harris is poised to make history on Wednesday as the first Black woman to accept a spot on a major party's presidential ticket, a moment intended to galvanize Democratic voters heading into the fall campaign against President Donald Trump.

This will be her second time speaking to the Democratic National Convention. But the stakes are higher than ever before as Harris tries to unite the party behind Joe Biden, while also introducing herself to a national audience that may be tuning into the campaign for the first time.

“For somebody with her wealth of background and experience, she's still fresh. She's still new,” said Ohio Rep. Marcia Fudge, a former chairwoman of the Congressional Black Caucus who endorsed Harris' 2020 presidential primary run before throwing her support behind Biden in March. “I think people are looking for that.”

Former President Barack Obama will speak ahead of Harris on Wednesday, the nation’s first Black president handing off to the first Black woman on a major presidential ticket. Harris will be introduced by her sister, Maya, and her niece Meena, as well as Ella Emhoff, her stepdaughter.

The senator's advisers say Harris will tell her story while highlighting the examples and experiences of others.

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Iowa governor's push to reopen schools descends into chaos

IOWA CITY, Iowa (AP) — An aggressive push by Iowa’s pro-Trump governor to reopen schools amid a worsening coronavirus outbreak has descended into chaos, with some districts and teachers rebelling and experts calling the scientific benchmarks used by the state arbitrary and unsafe.

The clash in the Midwest has illustrated in condensed form the tension between science and politics — and between economic concerns and health fears — that has characterized the nation's response to the outbreak from the White House on down. The virus has devastated the U.S. economy and killed over 170,000 Americans.

“We’re about to see a tragedy occur in the state. And there’s not a lot we can do about it. That’s frightening,” said Sara Anne Willette of Ames, a parent and former math tutor who runs a website tracking state infection data.

At issue is Republican Gov. Kim Reynolds’ mandate in July that districts offer at least 50% classroom instruction.

The conflict intensified Wednesday when the statewide teachers union announced a lawsuit challenging the governor's ability to make such decisions for local districts. The Iowa City school board, which like many others had planned to start the year fully online, voted to join the lawsuit.

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California governor: Hundreds of wildfires blazing statewide

VACAVILLE, Calif. (AP) — Crews were battling wildfires in the San Francisco Bay Area and thousands of people were under orders to evacuate Wednesday as hundreds of wildfires blazed across the state amid a blistering heat wave now in its second week.

Gov. Gavin Newsom blamed "this extraordinary weather we’re experiencing and all of these lightning strikes” for 367 known fires, including 23 major fires or groups of fires. He said the state has recorded nearly 11,000 lightning strikes in 72 hours.

Police and firefighters went door-to-door before dawn Wednesday in a frantic scramble to warn residents to evacuate as fire encroached on Vacaville, a city of about 100,000 between San Francisco and Sacramento. At least 50 structures were destroyed, including some homes, and 50 damaged.

“This is an incredibly emotional and stressful time for most of us who’ve endured a number of wildfires over the last few years," said Sonoma County Sheriff Mark Essick.

Ash and smoke filled the air in San Francisco, which is surrounded by wildfires burning in multiple counties to the north, east and south. The LNU Lightning fire is made up of several fires burning in five counties north of San Francisco, including in Vacaville, and had consumed 72 square miles as of Wednesday morning (186 square kilometers).

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Pelosi says postmaster has no plans to restore mail cuts

WASHINGTON (AP) — The Postal Service faced more questions and a federal lawsuit Wednesday over mail disruptions, despite assurances by President Donald Trump's postmaster general of no more service changes until after the November election — a pledge made only after a public outcry.

House Speaker Nancy Pelosi said Postmaster General Louis DeJoy told her he has no intention of restoring removed blue mailboxes or sorting equipment and no plans for employee overtime. Senate Democratic leader Chuck Schumer said officials are withholding information about DeJoy's selection to the job. With the agency in turmoil, civil and voting rights advocates are suing to bring mail operations back to normal.

Pelosi, D-Calif., said she told DeJoy in a phone call that his decision for a temporary pause was "wholly insufficient and does not reverse damage already wreaked.”

The uproar over the Postal Service is expected to spill out Friday as DeJoy testifies before the Senate, and Saturday as the House convenes for a rare session. The House is set to vote on legislation to reverse the service changes and provide $25 billion to shore up operations.

Widespread mail disruptions have stunned Americans and led to warnings that Trump is trying to undermine the Postal Service as he rails against mail-in ballots just as millions of people are trying vote absentee to avoid polling places during the COVID-19 crisis.

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Ex-FBI lawyer admits to false statement during Russia probe

WASHINGTON (AP) — A former FBI lawyer pleaded guilty Wednesday to altering a document related to the secret surveillance of a former Trump campaign adviser during the Russia investigation.

Kevin Clinesmith is the first current or former official to be charged in a special Justice Department review of the investigation into ties between Russia and Donald Trump's 2016 presidential campaign. Attorney General William Barr appointed John Durham, the U.S. attorney in Connecticut, to scrutinize decisions made by officials during that probe.

Clinesmith pleaded guilty to a single false statement charge, admitting that he doctored an email that the FBI relied on as it sought court approval to eavesdrop on former Trump campaign aide Carter Page in 2017.

The sentencing guidelines call for zero to six months in prison, but the punishment is ultimately up to U.S. District Judge James Boasberg, who accepted Clinesmith’s plea. Sentencing was scheduled for Dec. 10. Clinesmith resigned from the FBI before an internal disciplinary process was completed.

The case highlights broader problems with the FBI’s surveillance applications on Page, an issue that has long animated critics of the Russia investigation.

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Trail of bubbles leads scientists to new coronavirus clue

A doctor checking comatose COVID-19 patients for signs of a stroke instead stumbled onto a new clue about how the virus may harm the lungs -- thanks to a test that used tiny air bubbles and a robot.

Dr. Alexandra Reynolds, a neurologist at New York's Mount Sinai Health System, initially was baffled as she tracked “the cacophony of sound” made by those harmless bubbles passing through the bloodstream of patient after patient.

Yet the weird finding excited lung specialists who now are studying if it helps explain why often, the sickest coronavirus patients don't get enough oxygen despite being on ventilators.

The tale illustrates how months into the pandemic, scientists still are struggling to unravel the myriad ways the coronavirus attacks -- and finding hints in surprising places.

As patients flooded New York hospitals last spring, Mount Sinai’s intensive care unit that usually handles patients with brain diseases turned overnight into a COVID-19 ward, with patients heavily sedated as ventilators kept them alive.

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Apple reaches $2 trillion market value as tech fortunes soar

BERKELEY, Calif. (AP) — Apple has become the first U.S. company to boast a market value of $2 trillion as technology continues to reshape a world where smartphones are like appendages and digital services are like instruments orchestrating people's lives.

The iPhone maker reached the $2 trillion milestone in Wednesday's early stock market trading when its shares surpassed $467.77.

The stock later backtracked to close at $462.83, but it didn't diminish a remarkable achievement that came just two years after Apple became the first U.S. company with a $1 trillion market value. It comes amid a devastating pandemic that has shoved the economy into a deep recession and caused unemployment rates to soar to the worst levels since the Great Depression nearly a century ago.

But Apple and other well-established tech giants such as Microsoft, Google, Amazon, Facebook and Netflix have thrived during the upheaval as the pandemic has forced millions of people to work, attend classes, shop and entertain themselves at home. That, in turn, has made technology even more crucial, a factor that has caused investors to snap up the stocks of the industry's biggest players, as well as relative newcomers, such as video conferencing service Zoom, which has seen its shares quadruple so far this year.

Apple's stock has climbed nearly 58% this year. In recent weeks, the rally has been bolstered by excitement over a four-for-one stock split that Apple announced late last month in an effort to make its shares more affordable to a wider swath of investors.

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Palestinians in Gaza rally against Israel-UAE deal

GAZA CITY, Gaza Strip (AP) — Hundreds of Palestinians in the Gaza Strip on Wednesday rallied against the U.S.-brokered deal to normalize ties between Israel and the United Arab Emirates.

Protesters burned Israeli and American flags, trampled on posters of Israeli Prime Minister Benjamin Netanyahu and President Donald Trump, and chanted “normalization is betrayal to Jerusalem and Palestine.”

Unlike Palestinian protesters last Friday near the Al Aqsa Mosque compound in Jerusalem's Old City who also burned posters of the Emirati crown prince, the Gaza demonstrators stopped short of burning symbols of the UAE — apparently not to antagonize the Gulf Arab country, where tens of thousands of Palestinians work and live.

The demonstrators in Gaza City also voiced support for Palestinian President Mahmoud Abbas for his rejection of President Donald Trump's Mideast plan, which the Palestinians say unfairly favors Israel.

The protest was organized by the militant Hamas group, which rules the Gaza Strip, and other factions.

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FDA blocks much-anticipated BioMarin hemophilia gene therapy

FAIRLESS HILLS, PA (AP) — Investors fled drug developer BioMarin in droves on Wednesday, driving shares down by a third after U.S. regulators rejected the company’s potentially game-changing hemophilia A gene therapy over concerns it might not really be a one-and-done lifetime treatment.

The U.S. Food and Drug Administration's rejection late Tuesday means the San Rafael, California-based company will have to complete an ongoing late-stage patient study, likely delaying possible approval till late in 2022.

The infused therapy, called Roctavian, could have freed hemophilia A patients from frequent, extremely expensive infusions of a blood-clotting therapy to prevent dangerous internal bleeding. It had been highly anticipated by doctors, patients and investors.

In a statement, BioMarin said the company and the FDA previously agreed on how much patient testing data the agency required to review the therapy, but in its rejection letter the FDA for the first time recommended Biomarin finish the late-stage study and provide two years of follow-up data on the therapy’s safety and efficacy in preventing internal bleeding for all study participants.

The company added that FDA concluded differences between the results of a small, early-stage study and interim data from the late-stage study left unclear how long the therapy’s effect would last.