SAN FRANCISCO (AP) — Much of California is on the brink of sweeping new restrictions on businesses and activities, a desperate attempt to slow the frighteningly rapid escalation of coronavirus cases that threatens to overwhelm hospitals.

With a new lockdown looming, many rushed out to supermarkets Saturday and lined up outside salons to squeeze in a haircut before the orders in some areas take effect on Sunday.

Five San Francisco Bay Area counties imposed a new stay-at-home order for their residents that will take effect Sunday. Southern California and a large swath of the central portion of the state could join this weekend.

Those two regions have seen their intensive care unit capacity fall below the 15% threshold that under a new state stay-at-home order will trigger new restrictions barring all on-site restaurant dining and close hair and nail salons, movie theaters and many other businesses, as well as museums and playgrounds.

If their capacity remains below that level when the data is updated Saturday, the closures will take effect Sunday and stay in effect at least three weeks.

In San Francisco, resident Michael Duranceau rushed to a market to prepare for the new closures.

“I'm just stocking up before Sunday — the basics, bread, eggs," he told KGO-TV, clutching a heavy grocery bag and a baguette.

Gov. Gavin Newsom announced the new plan Thursday. It is the most restrictive order since he imposed the country's first statewide stay-at-home rule in March.

The new order divides the state into five regions and uses ICU capacity as the trigger for closures. Newsom also says people may not congregate with anyone outside their household and must always wear masks when they go outside.

As of Friday night, the 11-county Southern California region had only 13.1% of its ICU beds available, the California Department of Public Health reported. The figure was 14.1% for the San Joaquin Valley region, composed of a dozen counties in the agricultural Central Valley and rural areas of the Sierra Nevada.

The other three regions — Greater Sacramento, Northern California and San Francisco Bay Area — were all around 21%.

But health officers in five of the Bay Area's 11 counties didn’t wait. On Friday, they adopted the state's stay-at-home order. The changes begin to take effect Sunday night in San Francisco, Santa Clara, Marin, Alameda and Contra Costa counties, as well as the city of Berkeley.

“We don’t think we can wait for the state’s new restrictions to go into effect. ... This is an emergency,” Contra Costa Health Officer Chris Farnitano said.

“Our biggest fear all along — that we won’t have a bed for you or your mother or your grandmother or grandfather when they get sick — is the reality we’ll be facing unless we slow the spread,” San Francisco Mayor London Breed said.

The Bay Area order will last at least through Jan. 4, a week longer than the state's timeline, and came as the state recorded another daily record number of new cases with 22,018. Hospitalizations topped 9,000 for first time and ICU patients were at a record 2,152.

The new shutdowns were a gut-wrenching move for small businesses that have struggled to survive over nearly a year in which they were repeatedly ordered to close, then allowed to reopen but with complex safety precautions.

Michelle Saunders James was in tears Friday at the thought of closing down her Oakland nail salon just five weeks after reopening it.

“We wear (face) shields. We take temperatures. We do everything we are told to do so everyone feels safe, including our staff and team,” she told KGO-TV. “So I don’t understand why it’s not enough and I’m terribly sad and afraid.”

Under Newsom’s order, retail stores and shopping centers can operate with just 20% customer capacity.

In the East Bay, Berkeley Bowl’s two grocery stores already had laid in stocks of essentials in case of a return of panic buying that was seen after the state issued a strict stay-at-home order in mid-March that later was eased.

“We’ve learned valuable lessons from last time,” general manager Steve Tsujimoto told the San Francisco Chronicle. “We acted proactively and have been warehousing certain select items — toilet paper, sanitizers, wipes, beans, rice, grains, flour, bread — things of that nature.”

Critics say the broad statewide order unfairly lumps too many disparate counties together into regions.

The approach “places our ability to reopen with 10 other counties including Los Angeles County which has absolutely failed to control the coronavirus and Mono County whose most populous city is 344 miles away,” said Fred M. Whitaker, chairman of the Republican Party of Orange County.

The explosive rise in COVID-19 infections that began in October is being blamed largely on people ignoring safety measures and socializing with others.

Berkeley Health Officer Lisa Hernandez said people should not meet in person with anyone they don’t live with, “even in a small group, and even outdoors with precautions.”

“If you have a social bubble, it is now popped,” Hernandez said. “Do not let this be the last holiday with your family.”

Los Angeles County, the nation’s most populous with 10 million residents, could reach ICU capacity within days. Los Angeles Mayor Eric Garcetti said that could mean people with other life-threatening illnesses, such as strokes and heart attacks, might be unable to get a bed.

The city alone could see more than 11,000 lives lost to the virus by year’s end, the mayor said.

“That means 3,000 additional deaths in a single month. To put that in perspective, it’s a decade of homicides,” Garcetti said. “This is the greatest threat to life in Los Angeles that we have ever faced.”

In the inland Central Valley, Fresno County had just 10 of its 150 ICU beds available. Health officials described a grim picture with hospitals struggling to stay staffed because of coronavirus infections and exposures. One hospital is holding ICU patients in the emergency department until beds open up, Emergency Medical Services Director Daniel Lynch said Friday.

The county has requested help from the state with staffing for a couple of weeks. But so far only one or two additional workers have shown up at three local hospitals as the whole state struggles with staffing.

At Kaweah Delta medical center in Visalia, in Tulare County, there were 18 ICU beds available Friday but only the staff to handle four additional patients, said Keri Noeske, the chief nursing officer. Some 125 employees are out sick or quarantined because of COVID-19.

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Jablon reported from Los Angeles. Associated Press writer Jocelyn Gecker in San Francisco and Brian Melley in Los Angeles contributed.