NEW YORK (AP) — U.S. stocks tumbled following a sell-off in markets in Europe and Japan Monday after China announced a sharp rise in cases of a deadly new virus that threatens to crimp global economic growth.

Every major U.S. index gave up a significant amount of their gains for January and bond yields moved lower as investors headed for safer holdings. Airlines, resorts and other companies that rely on travel and tourism suffered steep losses. Gold prices rose.

Investors are in a “sell first, ask questions later situation,” said Alec Young, managing director of global markets research at FTSE Russell.

The S&P 500 index slumped 1.4% as of 9:46 a.m. Eastern time. The Dow Jones Industrial Average dove 420 points, or 1.5%, to 28,571. The Nasdaq fell 1.7%. The Russell 2000 index of smaller company stocks fell 1.2%.

Most markets in Asia were closed for the Lunar New Year holiday, but Japan’s Nikkei fell 2.03%, its biggest decline in five months. European markets also slumped. Germany’s DAX dove 2.4%.

Chinese health authorities have confirmed 2,744 cases of the coronavirus along with 81 related deaths as authorities extended a week-long public holiday by an extra three days as a precaution against having the virus spread still further. Despite the lockdown that has expanded to 17 Chinese cities, the coronavirus has spread to a dozen countries, including the U.S.

Global health authorities are increasingly on alert for any new cases. Besides the threat to people's lives and health, investors are worried about how much damage the virus will do to profits for companies around the world.

Even if they're thousands of miles away from Wuhan, the interconnected global economy means U.S. companies have plenty of customers and suppliers in China. It's the world's second-largest economy, and it accounts for 6% of all revenue for S&P 500 companies over the last 12 months. That's nearly double any other country besides the United States, according to FactSet.

“Markets hate uncertainty, and the coronavirus is the ultimate uncertainty in that no one knows how badly it will impact the global economy,” Young said.

Resort operators are reeling as the lockdowns in China directly threaten their businesses. Wynn Resorts fell 6.3% and Las Vegas Sands shed 6.6%. Those companies get the majority of their revenue from the Chinese gambling haven of Macao. MGM Resorts fell 3.8%.

American Airlines fell 6.7% and Delta slipped 3.9% as part of a broad slide for airlines because of concerns international travel will decline amid the virus’ spread.

Booking companies and cruise-line operators are also getting hurt. Expedia Group fell 3.5% and Carnival fell 3.7%.

Technology companies and banks were also among the losers in the early going. Apple, which relies on China for supplies and sales, slumped 2.6%. Citigroup fell 2.1%.

Energy stocks fell broadly as oil prices slipped 1.6%. Schlumberger fell 3.7%.

Utilities and real estate companies held up better than most of the market. Both sectors are viewed as less-risky and are little-affected by international issues and developments.

Investors are also dealing with a heavy week of corporate earnings. Apple will report financial results on Tuesday. Pharmaceutical giant Pfizer and Starbucks will also report.

Boeing, McDonald’s, Coca-Cola and Amazon are also among some of the biggest names reporting earnings throughout the week that includes 147 S&P 500 companies.