CAIRO (AP) — An international aid group said Wednesday that closures aimed at containing the coronavirus pandemic are preventing it from reaching 300,000 people in conflict zones across the Middle East, after authorities in Libya's capital reported the first case in the war-torn country.

The Norwegian Refugee Council said it was unable to reach people in Syria, Yemen and the Gaza Strip, where authorities have imposed strict measures to halt the spread of the virus. All have fragile health care systems that could be overwhelmed by an outbreak, and only Yemen has yet to report any cases.

“While governments are taking tough and much-needed measures to prevent the spread of coronavirus, millions of refugees and displaced people still depend on humanitarian assistance,” said Jan Egeland, head of the aid group.

“If supermarkets and pharmacies can remain operational during this crisis, then so should the delivery of humanitarian aid,” he added.

For most people, the new coronavirus causes mild or moderate symptoms, such as fever and cough that clear up in two to three weeks. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia and death. The virus is highly contagious and can be spread by those showing no symptoms.

Countries across the Middle East have imposed sweeping measures to prevent its spread, including closing their borders, cancelling flights and in some cases imposing round-the-clock curfews that confine people to their homes.

The Israeli government on Wednesday approved new restrictions, including the closure of all synagogues. Authorities across the region have already shuttered major holy sites sacred to Christians, Muslims and Jews.

Many in Israel's insular ultra-Orthodox communities have defied restrictions on public gatherings, despite the pleas of rabbis and local authorities. That has led to tension with authorities and in at least one case, scuffles with police. Municipal workers also have been urging the ultra-Orthodox to go home, with little effect.

The order to close the synagogues, which goes into effect later Wednesday, reportedly came over the objection of Israel's health minister, himself an ultra-Orthodox Jew.

The new restrictions in Israel will bar most people from venturing more that 100 meters (yards) from their homes. More than 2,000 Israelis have been infected, with 37 in serious condition. Five elderly Israelis with pre-existing medical conditions have died.

The Palestinian Authority, which governs parts of the Israeli-occupied West Bank, has ordered a full lockdown and halted travel between cities, towns and villages after reporting 58 cases.

But late Tuesday, hundreds of people in the northern West Bank town of Jenin, including dozens of armed men, defied the restrictions when they held a rally to celebrate the release of a Palestinian prisoner from an Israeli jail.

Also late Tuesday, the Palestinian Authority ordered all Palestinian workers to return to the West Bank from Israel, which had allowed around 65,000 to stay and work during the crisis.

Many Palestinians work in construction, agriculture and manufacturing in Israel. Wages in Israel are much higher than in the Palestinian territories, where decades of Israeli military rule has hindered economic development.

In Libya, officials say a 73-year-old man who entered from neighboring Tunisia on March 5 tested positive. The Libyan patient had recently traveled to Saudi Arabia, according to Libya's National Center for Disease Control, and was receiving medical treatment for his fever and cough in isolation at a Tripoli hospital.

Libya has been mired in chaos since the 2011 uprising that overthrew and killed longtime dictator Moammar Gadhafi. It is governed by rival authorities based in Tripoli and eastern Libya whose forces have been battling over the capital for nearly a year. Each is supported by a patchwork of armed groups.

On Tuesday, Tripoli's suburbs came under heavy fire even as the United Nations appealed for a truce so authorities could focus on preventing the spread of the coronavirus.

In neighboring Egypt, Prime Minister Moustafa Madbouly said a nationwide curfew from 7 p.m. until 6 a.m. would go into effect Wednesday, during which public transportation would come to a halt. Egypt has confirmed 402 cases and 22 fatalities, including two senior military officers who were involved in efforts to disinfect public places.

Pakistan halted all domestic passenger flights beginning Thursday after reporting nearly 1,000 cases. It had previously suspended train service and international flights. The outbreak in Pakistan was initially confined to people who had recently traveled to Iran but now appears to be circulating among those with no recent travel history.

Iran is battling the worst outbreak in the region, with over 27,000 confirmed cases and a death toll of at least 2,077, Health Ministry spokesman Kianoush Jahanpour said Wednesday.

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Heller reported from Jerusalem. Associated Press writers Munir Ahmed in Islamabad; Jon Gambrell in Dubai, United Arab Emirates; Jan M. Olsen in Copenhagen,Denmark; Mohammed Daraghmeh in Ramallah, West Bank; Nasser Karimi in Tehran, Iran, and Joseph Krauss in Jerusalem contributed to this report.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.